Development of wearable medical technology for remote monitoring of patients suffering from chronic lung diseases may improve the care, therapy and outcome of these patients. Approach: A multimodal system using wearable sensors for the acquisition of multiple biosignals (electrical bioimpedance of the chest for electrical impedance tomography and respiratory rate assessment, peripheral oxygen saturation, chest sounds, electrocardiography for heart rate measurement, body activity, and posture) was developed and validated in a prospective, monocentric study on 50 healthy subjects. The subjects were studied under different types of ventilation (tidal and deep breathing, forced full expiration maneuver) and during increased body activity and posture changes. The major goals were to assess the functionality by determining the presence and plausibility of the signals, comfort of wearing and safety of the vest. Results: All intended signals were recorded. Streaming of selected signals and wireless download of complete data sets were functional. Electrical impedance tomography recordings revealed good to excellent quality of detection of ventilation-related impedance changes in 34 out of 50 participants. Respiratory and heart rates were reliably detected and generally in physiological ranges. Peripheral oxygen saturation values were unphysiologically low. The chest sound recordings did not show waveforms allowing meaningful analysis of lung sounds. Body activity and posture were correctly identified. The comfort of wearing and the vest properties were positively rated. No adverse events occurred. Significance: Albeit the full functionality of the current vest design was not established, the study confirmed the feasibility of remote functional chest monitoring with a marked increase in clinically relevant information compared to existing systems.