Welcome to YODA – Open Digital Archive for CSEM

The YODA archive gives access to CSEM's publications, such as its annual reports and brochures. For technical papers such as scientific publications, bibliographic information is provided, along with the full paper where this is possible.

This comprehensive database is part of CSEM's Open Access Publishing policy. For further information refer to the YODA support guide or contact repository@csem.ch.

Recent Submissions

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    CRISPR-based one-pot assay for the detection of monoclonal antibodies
    (2023-11-14) Del Giovane, Stefano; Migliorelli, Davide; Bagheri, Neda; Porchetta, Alessandro; Altug, Hatice; Burr, Loïc
    Monoclonal antibodies (mAbs) are established therapies for malignancies, autoimmune and infection diseases. However, the administration of mAbs carries the risk of adverse effects and the development of resistance to the therapy by the production of anti-mAb antibodies. For these reasons, monitoring the serum concentration of the mAbs become crucial especially in cancer drug therapies. We present a novel Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based assay for mAbs detection that is simple to use and sensitive in the range of interest for the mAbs concentration in blood.
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    Physiological and degenerative loading of bovine intervertebral disc in a bioreactor: A finite element study of complex motions
    (2023) Ristaniemi, Aapo; Secerovic, Amra; Dischl, Vincent; Crivelli, Francesco; Heub, Sarah; Ledroit, Diane; Weder, Gilles; Grad, Sibylle; Ferguson, Stephen J.
    Intervertebral disc (IVD) degeneration and regenerative therapies are commonly studied in organ-culture experiments with uniaxial compressive loading. Recently, in our laboratory, we established a bioreactor system capable of applying loads in six degrees-of-freedom (DOF) to bovine IVDs, which replicates more closely the complex multi-axial loading of the IVD in vivo. However, the magnitudes of loading that are physiological (able to maintain cell viability) or mechanically degenerative are unknown for load cases combining several DOFs. This study aimed to establish physiological and degenerative levels of maximum principal strains and stresses in the bovine IVD tissue and to investigate how they are achieved under complex load cases related to common daily activities. The physiological and degenerative levels of maximum principal strains and stresses were determined via finite element (FE) analysis of bovine IVD subjected to experimentally established physiological and degenerative compressive loading protocols. Then, complex load cases, such as a combination of compression + flexion + torsion, were applied on the FE-model with increasing magnitudes of loading to discover when physiological and degenerative tissue strains and stresses were reached. When applying 0.1 MPa of compression and ±2–3° of flexion and ±1–2° of torsion the investigated mechanical parameters remained at physiological levels, but with ±6–8° of flexion in combination with ±2–4° of torsion, the stresses in the outer annulus fibrosus (OAF) exceeded degenerative levels. In the case of compression + flexion + torsion, the mechanical degeneration likely initiates at the OAF when loading magnitudes are high enough. The physiological and degenerative magnitudes can be used as guidelines for bioreactor experiments with bovine IVDs.
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    Chat GPT and other AI´s – a new language for the industry
    (2023-11-22) Schmid, Philipp A. E.
    Since the free launch of the ChatGPT chatbot in 2022, Artificial Intelligence (AI) has undeniably become a hot topic. More than 50% of ChatGPT users reveal that they utilize AI in their personal lives to streamline daily tasks. With such widespread consumer interest in AI, it prompts a natural inquiry into the current role of AI in the industrial landscape. Philipp Schmid, Head of Industry 4.0 and Machine Learning at CSEM, an internationally recognized Swiss technology innovation center, provides insights in the following interview. Schmid addresses, among other topics, the general significance of AI in the industry, the untapped potential of predictive maintenance and why the industry would do well to rethink its handling and attitude toward data.
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    (2023-04-05) Bernard, Gaëtan; Pejchal, Vaclav; Larsson, Joel; Sereda, Olha; Logé, Roland
    This study presents a production method of high stiffness Ti-TiC Metal Matrix Composite by Laser Powder Fusion. Crack and porosity free samples were printed with an improved Young’s modulus of up to 163 GPa showing a 39% increase compared to commercially pure Titanium produced by the same method. Microstructure shows both un-melted TiC particles and sub-stoichiometric TiC dendrites resulting from partial dissolution of TiC particles. The observed low C/Ti ratio leads to an effective reinforcement content more than twice the nominal one. Effects of post-treatments on microstructure and mechanical properties are presented.
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    Die Technologiewelle rollt – Hochleistungsproduktion in der Schweiz dank Daten und KI
    (2023-11-23) Schmid, Philipp A. E.; Steinecker, Alexander
    AI setzt sich immer stärker im Alltag durch: Übersetzungsprogramme, lustige Fotofilter auf dem Handy oder Fahrassistenzen im Auto. Nun steht der grosse Durchbruch in der produzierenden Industrie an. Perfekte Qualität und immer höhere Effizienz treiben Schweizer Firmen. Viele Betriebe haben begonnen, Daten von Maschinen und Prüfgeräten zu speichern, häufig lokal in unterschiedlichen Formaten und Tabellen auf verschiedenen Geräten. Nun ermöglichen fallende Preise und die einfache Handhabung von IoT-Gateways die Anbindung an die Cloud. Die Daten verweilen nicht länger in verteilten Silos, sondern lassen sich entlang ganzer Wertschöpfungsketten und auch standortübergreifend aggregieren. Neue Konzepte wie Predictive Quality bieten ganzheitliche Lösungsansätze um aus dem Datenberg einen echten Wettbewerbsvorteil zu ziehen. Doch obwohl künstliche neuronale Netzwerke bereits seit einem Jahrzehnt gross in aller Munde sind, gelang es der Industrie bisher kaum davon zu profitieren. Philipp Schmid analysiert in seinem Referat, wo die Technologie heute steht, benennt die Stolpersteine und zeigt anhand konkreter Beispiele das enorme Potential von Data Science und KI in der Industrie auf. Im bevorstehenden INNOtalk #6 möchte die SwissICT Fachgruppe Innovation relevante Aspekte dieses Themas in einer interaktiven Art und Weise diskutieren und freut sich auf die Teilnahme des Experten Philipp Schmid sowie allen anwesenden Gästen. Eine angenehme Atmosphäre mit viel Gelegenheit für wertvolles Networking rundet diesen Anlass ab.

Communities in YODA

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  • CSEM Archive
    The YODA archive contains two collections. The “Research Publications” collection provides bibliographic information for scientific papers including conference proceedings and presentations. And the "Marketing Material" collection includes corporate reports, brochures, and more.