Welcome to YODA – Open Digital Archive for CSEM
The YODA archive gives access to CSEM's publications, such as its annual reports and brochures. For technical papers such as scientific publications, bibliographic information is provided, along with the full paper where this is possible.
This comprehensive database is part of CSEM's Open Access Publishing policy. For further information refer to the YODA support guide or contact repository@csem.ch.
Recent Submissions
Item Multi-well plate lid for single-step pooling of 96 samples for high-throughput barcode-based sequencing.(2024-02-28)High-throughput transcriptomics is of increasing fundamental biological and clinical interest. The generation of molecular data from large collections of samples, such as biobanks and drug libraries, is boosting the development of new biomarkers and treatments. Focusing on gene expression, the transcriptomic market exploits the benefits of next-generation sequencing (NGS), leveraging RNA sequencing (RNA-seq) as standard for measuring genome-wide gene expression in biological samples. The cumbersome sample preparation, including RNA extraction, conversion to cDNA and amplification, prevents high-throughput translation of RNA-seq technologies. Bulk RNA barcoding and sequencing (BRB-seq) addresses this limitation by enabling sample preparation in multi-well plate format. Sample multiplexing combined with early pooling into a single tube reduces reagents consumption and manual steps. Enabling simultaneous pooling of all samples from the multi-well plate into one tube, our technology relies on smart labware: a pooling lid comprising fluidic features and small pins to transport the liquid, adapted to standard 96-well plates. Operated with standard fluidic tubes and pump, the system enables over 90% recovery of liquid in a single step in less than a minute. Large scale manufacturing of the lid is demonstrated with the transition from a milled polycarbonate/steel prototype into an injection molded polystyrene lid. The pooling lid demonstrated its value in supporting high-throughput barcode-based sequencing by pooling 96 different DNA barcodes directly from a standard 96-well plate, followed by processing within the single sample pool. This new pooling technology shows great potential to address medium throughput needs in the BRB-seq workflow, thereby addressing the challenge of large-scale and cost-efficient sample preparation for RNA-seq.Item Inkjet Printed Optical Waveguides(2017)Optical waveguide structures have been inkjet-printed with a special technique relying on the formation of capillary bridges. The optical losses amounted to 0.61 dB/cm on average with the best waveguides performing at 0.2 dB/cm, highlighting the precision with which the features were deposited. Besides waveguide-based applications like sensing or data transfer, the developed printing technique could also easily be adapted to other structures or materials to enable rapid prototyping and actual production alike.Item Künstliche Intelligenz in der Industrie(2024-11-27)Künstliche Intelligenz verändert rasant die industrielle Welt und eröffnet neue Möglichkeiten von der Fertigung bis zur Instandhaltung. Mario Russi, Experte für KI und Robotik, zeigt konkrete Anwendungen und erfolgreiche Praxisbeispiele aus Schweizer Unternehmen. Er beleuchtet die Chancen und Herausforderungen von KI-Technologien und gibt einen Ausblick auf zukünftige Entwicklungen in der Industrie.Item Development of hybrid photonic integrated wavelength-tunable laser at 2 μm and its application to FMCW LiDAR(2024-06-17)This paper reports on the experimental demonstration of a fully integrated frequencymodulated continuous-wave (FMCW) LiDAR sensing system, operating at 2.0 μm. It makes use of a widely tunable hybrid external cavity laser based on the combination of GaSb gain chip and silicon waveguide circuits. The single-frequency laser operation over the full spectral bandwidth of the gain chip is secured using a frequency-selective filter, consisting of two sequential microring resonators in a Vernier configuration. To increase the mode-hop free wavelength tuning range while preserving the linewidth of the laser, the heater of the phase section placed along the bus waveguide is synchronously controlled with two independent heaters placed on each microring resonator. This laser is then implemented for the development of an FMCW LiDAR, consisting of all-optical fiber-based two independent unbalanced Mach-Zehnder interferometers: k-space interferometer for the linearization of continuously swept laser frequency and main interferometer for the measurement of the distributed back-reflection over the distance. The optical frequency of the laser is continuously swept over a ∼100 GHz range (or Δλ=1.47 nm at the operating wavelength) at a modulation speed of 100 Hz. Using this wavelength tunable laser, a light detection and ranging system (LiDAR) is experimentally demonstrated, showing a very high axial resolution of 1.36 mm in air with an extremely high precision of ∼9 μm at a 100 Hz measurement rate.Item Digital OPLL-based distributed Brillouin sensing system in optical fibers(2022-05-23)digital optical phase-locked loop (OPLL) has been implemented to develop a distributed Brillouin sensing system in optical fibers. In our experiment, two commercial semiconductor lasers are phase-locked to each other with a highly flexible offset frequency using field programmable gate array (FPGA)-based electronics. Then, the difference frequency between the two lasers is highly stabilized and scanned by a desired step frequency in the vicinity of the Brillouin frequency of standard single-mode optical fibers. Consequently, the distribution of Brillouin frequency shift over a 50 km-long sensing fiber has been successfully measured by a very simple and low-cost Brillouin optical time-domain reflectometry (BOTDR) sensing system without any penalty in the sensing performance. The measurement repeatability at 50 km position of sensing fiber with a 5 m spatial resolution was measured be 4.5MHz under fast measurement conditions: the number of trace averaging of 2000 and the frequency scan step of 12.8 MHz, showing the figure-of-merit of 3.0.
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