CRISPR-Cas Systems
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Author
Del Giovane, S.
Migliorelli, D.
Burr, L.
Altug, H.
Porchetta, A.
DOI
Abstract
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based diagnostics have emerged as promising tool to revolutionize molecular diagnostics. Despite notable progress, challenges exist in utilizing CRISPR platforms for point-of-care (POC) applications, such as amplification steps and a focus on non-nucleic acids target detection. We propose an innovative approach, exploiting a DNA circuit, to detect antibodies with an amplification-free CRISPR-based assay.
Publication Reference
CSEM Scientific and Technical Report 2023, p. 84.
Year
2023