Polysaccharides for functional biomolecule display on surfaces
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Author
Caelen, Norbert
Gao, Hui
Sigrist, Hans
Abstract
Glycoconjugates of different molecular configurations are part of many vital
biological processes, including molecular recognition, surface adhesion and
cellular signalling. Functional molecular display on surfaces is a prerequisite
for conclusive determination of glycoconjugate function and for the integration
of bioactive carbohydrate structures in analytical platforms, in biomimetic
surfaces or in medical devices. Glycans functionalised with light-sensitive
aryldiazirine groups are used to establish biocompatible matrices. Thinfilm
coats of glycan-based linker polymers allow for single-step covalent
attachment of glycoconjugates, glycans and proteins, each of them displaying
innate molecular functions on target surfaces.
Publication Reference
Langmuir 2002 18 (7), 2463-2467
Year
2005-09-01