Polysaccharides for functional biomolecule display on surfaces
Glycoconjugates of different molecular configurations are part of many vital biological processes, including molecular recognition, surface adhesion and cellular signalling. Functional molecular display on surfaces is a prerequisite for conclusive determination of glycoconjugate function and for the integration of bioactive carbohydrate structures in analytical platforms, in biomimetic surfaces or in medical devices. Glycans functionalised with light-sensitive aryldiazirine groups are used to establish biocompatible matrices. Thinfilm coats of glycan-based linker polymers allow for single-step covalent attachment of glycoconjugates, glycans and proteins, each of them displaying innate molecular functions on target surfaces.
as published in BTi September 2005