Handheld SWIR optical reader for monitoring carbon nanotube-based optical sensors

dc.contributor.authorZubkovs, Vitalijs
dc.contributor.authorLeeners, Keno J.
dc.contributor.authorCattaneo, Stefano
dc.date.accessioned2022-12-08T15:01:56Z
dc.date.available2022-12-08T15:01:56Z
dc.date.issued2022-12-06
dc.descriptionReferences 1. Cai, Y., et al., Optical nano-agents in the second near-infrared window for biomedical applications. Chemical Society Reviews, 2019. 48(1): p. 22-37 2. Hofferber, E.M., et al., Implantable Nanotube Sensor Platform for Rapid Analyte Detection. Macromolecular bioscience, 2019. 19(6): p. 1800469 3. Zubkovs, V., et al., Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring. Nanoscale Advances, 2022. 4(11): p. 2420-2427 4. Iverson, N.M., et al., In vivo biosensing via tissue-localizable near-infrared fluorescent single-walled carbon nanotubes. Nature nanotechnology, 2013. 8(11): p. 873-880en_US
dc.description.abstractSingle-walled carbon nanotubes (SWCNTs) are known as highly sensitive biosensors with great potential for both in vitro and in vivo applications1,2,3. SWCNT-based sensors demonstrate inherent photostability, can be tailored to detect a wide range of analytes, and are particularly suited for in vivo applications due to the SWCNT fluorescence emission in the SWIR optical region (900-1700 nm). Long-term animal study after subcutaneous implantation in mice for 400 days4 showed that hydrogel-encapsulated SWCNTs sensors do not cause an inflammatory reaction, nor are they toxic to the animal. This sensor technology is very promising, but until now its application has been limited to research laboratories due to the lack of affordable and portable sensor monitoring equipment. As part of the Innosuisse project NIOXIS, we developed a prototype handheld SWIR reader. The reader consists of an InGaAs imaging camera and circular illumination light source. The fluorescence images of the SWCNT sensors are captured and analyzed using our own developed NIOXIS software. In this study, the feasibility and functionality of the prototype device is presented. The target application of NIOXIS is real-time monitoring of inflammation over longer periods of time and assessment of NO level in joints associated with chronic pathologies.en_US
dc.identifier.citationBiomedical Photonics Network, Book of Abstracts, Poster 15en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12839/1070
dc.language.isoenen_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectSWCNTen_US
dc.subjectsensorsen_US
dc.subjectnanotubeen_US
dc.subjectSWIR cameraen_US
dc.titleHandheld SWIR optical reader for monitoring carbon nanotube-based optical sensorsen_US
dc.typeConferenceen_US
dc.type.csemdivisionsDiv-Ren_US
dc.type.csemresearchareasTools for Life Sciencesen_US
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