Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes
Loading...
Author
Burr, Loïc
Paoletti, Samantha
Cattaneo , Stefano
Chai-Gao, Hui
Cristofolini, Peter
DOI
DOI: 10.1080/25785826.2025.2504021
Abstract
Gestational diabetes mellitus (GDM) is linked to an imbalance in gut microbiota composition,
which can be transferred to the mother’s offspring. Clostridium butyricum, known for its health
benefits in diabetes and allergy, lacks sufficient data regarding its effect on the immune
system’s development in the offspring of mothers with GDM. This study assessed antibody
responses against C. butyricum T2F3 in children of mothers at risk for GDM, involving 88
children aged 1–6 years. Antibody responses were measured with flow cytometry and
immunoblot. Lower IgG median fluorescence intensity (MFI) values and fewer IgA and IgG
bands against C. butyricum were detected in children of mothers with GDM. Maternal body
mass index was positively associated with children’s IgG MFI and number of IgG bands. Fewer
IgA bands were detected in children with higher IgE levels, atopic dermatitis, asthma, and
allergic rhinitis. More IgG bands were detected in children with higher anti-β-lactoglobulin IgG
levels. Children with autoimmune risk-related HLA-DR3/DQ2.5 had fewer IgA bands, while
those with neutral HLA-DR1/DQ5 had higher IgA, but lower IgG MFI. These results indicate
that maternal prenatal changes could affect their offspring’s immune response against
C. butyricum. Moreover, C. butyricum could have a protective role against allergic sensitization.
Publication Reference
Celeste Peterson, Aili Tagoma, Kristi Alnek, Anu Bärenson, Tamara Vorobjova, Ija Talja, Helis Janson, Anne Kirss, Siiri Kõljalg, Aki Sinkkonen, Marja Irmeli Roslund, Raivo Uibo & the HEDIMED Investigator Group (23 May 2025): Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes, Immunological Medicine, DOI: 10.1080/25785826.2025.2504021
Year
2025-05-23