Label-free non-contact glucose monitoring in organ-on-a-chip systems using NIR/MIR spectroscopy
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Author
Zubkovs, Vitalijs
Möhr-Vorobeva, Ekaterina
Beyer, Christian
Lovera, Andrea
Bleich, Clara
Cattaneo, Stefano
DOI
Abstract
We present one of the PhotonMed pilot-cases which aims to revolutionize glucose monitoring in organ-on-a-chip (OoC) devices through the development of a non-invasive, label-free real-time monitoring system using near-infrared (NIR) and mid-infrared (MIR) spectroscopy. This innovative approach addresses the current limitations of glucose monitoring in OoC systems, which require invasive sampling methods that are not feasible for continuous monitoring and can lead to contamination. The primary objective of this pilot project is to develop a compact, competitive NIR/MIR reader capable of continuous glucose monitoring in OoC devices. The developed system is validated for glucose measurement and is intended for use in biological laboratories, bioproduction facilities, pharmaceutical companies, biotech production, and advanced biological research. It provides non-invasive, continuous glucose monitoring in low-volume cell culture media. In the current study we present a proof-of-concept validation of the measurement approach. Further studies will validate this system using a liver-pancreas assay to monitor glucose concentration in the cell culture compartment of the OoC.
Publication Reference
EPoSS Annual Forum 2025 Poster Nb 13
Year
2025-06-05
Sponsors
Co-funded by the European Union and Swiss State Secretariat for education, Research and Innovation.